Margaret I. Cuomo is an American radiologist, author, philanthropist, advocate, and blogger on health issues, especially those related to cancer prevention. She is the eldest daughter of former New York Governor Mario Cuomo and former New York First Lady Matilda Cuomo, and sister to current New York Governor Andrew Cuomo.

Margaret specializes in body imaging, involving CT, Ultrasound, MRI, and interventional procedures, much of her practice was dedicated to the diagnosis of cancer and AIDS. She has been interviewed and featured in such publications as Better Homes and Gardens, Glamour, InStyle, Manhattan, Metro Newspapers, New York Daily News, O Magazine, Parade, Vogue, Women's Day, Glamour, DailyBeast and many more. She resides in New York.